Li, Eric Youshao, George Tellides, and Jay D. Other authors of this study are Jens Hansen, Ravi Iyengar, Keiichiro Tanaka, Pengwei Ren, Abdulrahman Hassab, David S. These findings suggest a potential therapeutic strategy for the treatment of MFS by targeting the adverse signaling pathways involving FN-integrin α5. The study highlights the NF-kB pathway as a critical regulator of the SMC phenotypic switching in the presence of FN. They found that the mutation in integrin α5/2 greatly prolonged the survival of Marfan mice and improved the integrity of elastic fibers, mechanical properties, SMC density, and SMC contractile gene expression. The authors used integrin α2 chimeric mice, crossed with Fbn1mgR/mgR (mgR: animal model of Marfan syndrome), to investigate the molecular mechanisms by which FN affects SMCs. This occurs by decreasing contractile gene expression and activating inflammatory pathways (via integrin α5-NF-kB signaling), both of which contribute to aneurysm development. This leads to the destabilization of elastic fibers and accumulation of fibronectin (FN) in the extracellular matrix, which can contribute to the development of aortic aneurysms.įirst authors Minghao Chen, PhD, and Cristina Cavinato, PhD, demonstrate that the increase in FN, resulting from fibrillin insufficiency, affects smooth muscle cells (SMCs). MFS is caused by mutations in the FBN1 gene that encode fibrillin-1. MFS is a genetic disorder which affects the development of stable connective tissue, including the aorta. Berliner Professor of Medicine, and professor of biomedical engineering and of cell biology, published in the journal Arteriosclerosis, Thrombosis and Vascular Biology, suggests that fibronectin amplifies inflammatory responses through its main receptor, integrin α5β1 in MFS. Recently a study by Martin Schwartz, PhD, Robert W. This item can’t be shipped, the buyer must pick up the item.A Yale-led study has discovered a new way to potentially treat aortic aneurysms (AA), a condition where the aorta ruptures, in individuals with Marfan Syndrome (MFS). The seller is “mbtae55″ and is located in Gwinn, Michigan. This item is in the category “Collectibles\Transportation\Automobilia\Gas Pumps & Fueling Systems”. The item “Martin Schwartz vintage Gas Pump model 80Texaco/gaspump” is in sale since Monday, June 27, 2016. PRICE 1,975.00 or REASONABLY CLOSE OFFER. WAS JUST THE RIGHT LOOK OR RESTORE TO YOUR FAVORITE GASOLINE BRAND. This is heavy even with the pump removed from the inside. 1940’s MARTIN & SCHWARTZ GAS PUMP TALL BASE MODEL 80 SERIES 4BR. There is a small crack on the eagle part but no problem. The helmet has a speaker built in and still works. The Texaco fire chief helmet was a promotional thing done back in the 60’s. The car is a old new stock pedal car still in the box. This is a high boy with the high base and stands over 7′. The globe is new as well as the porcelain signs. This pump was restored with most of the original parts. Thereafter all pumps were branded Wayne until the plant closed in the early years of 2000. Martin & Schwartz 80 - Faces white powder coated, embossed & formed 55/set (these do not have a hole on top for the site glass). with 2 mntg holes, black numbers on a white background - 20 each. These pumps were manufactured in Salisbury, Maryland until the early fifties. View Martin Schwartz results in New Jersey (NJ) including current phone number, address, relatives, background check report, and property record with Whitepages. Martin & Schwartz 70 (Farm pump) - Face - 6' dia. Here we have a Martin & Schwartz 80 gas pump done in Standard Texaco gasoline colors.
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